Human and Rat Neocortical Development

The book, Human Neocortical Development, is a sequel to our 1991 book, Neocortical Development, in the rat (presented below).  We used our extensive photographic library of human embryonic, fetal, and some neonate specimens along with the sparse classical literature on human neocortical development.  Some important developmental events, like the partitioning of the stratified transitional field (STF, the old intermediate zone) into distinctive lamination patterns of interacting migrating neurons and incoming and outgoing axons, are presented in an expanded set of diagrams and illustrations.  The STF was discovered in rats, and it is much more pronounced in humans.  Please see the link below for a 2002 paper on the human STF that appeared in the Journal of Neurocytology.  STF documentation photographs were illustrated in our 5-volume series, Atlas of Human Central Nervous System Development.  This book treats that topic, and many other new observations in a concentrated look at only the human neocortex.  The greatest part of the book is a series of annotated illustrations showing early to late developmental events, beginning with the appearance of the neocortical neuroepithelium and ending with an extensive documentation of myelination sequences and the appearance of cortical gyri.  The book concludes with a discussion of hypotheses and interpretations of neocortical circuitry development and introduces a novel concept about an anchoring system that establishes the depths of early fissures and gyri in the initially smooth cortex. The illustrations on the right explain our hypothesis of an anchoring system (modified from Figure 80B, top and Figure 81, bottom) in the final part of the book.

The link below is the pdf file of the entire book containing over 200 pages; the file is nearly 25 MB because of the extensive photographs included.  The Laboratory of Developmental Neurobiology is offering this as a free book to anyone who wishes to learn more about human neocortical development.  Enjoy reading!  Please use the contact page to let us know what you think of our interpretations.