Adult Neorogenesis
The Discovery
The arrow indicates a labeled hippocampal granule cell in a young adult rat that was injected two times intraperitoneally with 3H-thymidine at 4 months (one week interval between injections) and survived to 5 months (counterstained autoradiogram). This is Figure 13 in the above paper and is the first illustration (among others in the paper) of a hippocampal neuron generated during the adult period.
INFORMATION ADDED OCTOBER, 2014: A brief communication from our laboratory documents the histological evidence for a subgranular zone in the dentate gyrus of children aged 1 month to 6 years. This finding supports the hypothesis that the dentate granular layer in humans has the same developmental pattern as in other mammals.
BRIEF COMMUNICATiON 1: HIPPOCAMPAL POSTNATAL NEUROGENESIS IN CHILDREN
Altman Science 1962.pdf–first demonstration of labeled neurons in adult brains
Bayer et al Science 1982.pdf–the dentate granule cell population grows in adults
Altman&Bayer hippo dev 1975.pdf–review paper on dentate gyrus development
Altman Anat Rec 1963.pdf–adult neurogenesis in hippocampus and cerebral cortex
Altman&Das JCN 1965.pdf–early postnatal and adult neurogenesis in hippocampus
Bayer-Exp Br Res 1982.pdf–method for determining that the granule cell population is actually growing