Human and Rat Neocortical Development
The Development of the Human Neocortex
The link below is the pdf file of the entire book containing over 200 pages; the file is nearly 25 MB because of the extensive photographs included. The Laboratory of Developmental Neurobiology is offering this as a free book to anyone who wishes to learn more about human neocortical development. Enjoy reading! Please use the contact page to let us know what you think of our interpretations.
The Development of the Rat Neocortex
The photo series here shows the different levels we used to determine the time of origin of neurons in different parts of the neocortex with 3H-thymidine autoradiography (Chapter 3, Figure 3-6; pdf file #5, bottom list). L1-L5 are the levels from most anterior (1) to most posterior (5).
We think that the concepts presented in this book are relevant today, and this developmental treatise remains the most comprehensive study of neocortical development in any mammal. The recent research on gene expression studies confirms some of our observations and speculations about the mechanisms at work during neocortical development.
Links to papers on Rat Neocortical Development in Refereed Journals:
1 Altman&Bayer Exp Neurol 107 1
2 Altman&Bayer Exp Neurol 107 2
Rat Neocortical Development Book Files By Part and Chapter
File Download:
1 NCD front.pdf | Table of Contents, Preface, Acknowledgements
2 NCD Pt 1.pdf | One page listing of the chapters on major developmental events
3 NCD Ch 1.pdf | Historical review of early cortical development
4 NCD Ch 2.pdf | Chronological Atlas of morphogenesis and histogenesis
5 NCD Ch 3.pdf | Overview of neurogenetic gradients
6 NCD Pt 2.pdf | One page listing of the chapters on embryonic development
7 NCD Ch 4.pdf | The germinal matrix
8 NCD Ch 5.pdf | The primordial plexiform layer, Layer l and the Subplate
9 NCD Ch 6.pdf | The cortical plate
10 NCD Ch 7.pdf | The cortical transition field
11 NCD Ch 8.pdf | Nuclear area and orientation quantitative studies
More Downloads:
14 NCD Pt 3.pdf | One page listing of the chapters on neurogenetic gradients
15 NCD Ch 11.pdf | Visual areas
16 NCD Ch 12.pdf | Auditory areas
17 NCD Ch 13.pdf | Somatosensory areas
18 NCD Ch 14.pdf | Motor areas
19 NCD Ch 15.pdf | Limbic areas
20 NCD Pt 4.pdf | One page listing of summary chapters
21 NCD Ch 16.pdf | Theoretical issues
22 NCD Ch 17.pdf | Summary and conclusions
23 NCD appendix.pdf | Detailed explanation of methods, including 3H-thymidine autoradiography