Cerebellar Development

Development of the Cerebellum

The cerebellum, with its highly geometric cytoarchitecture, is one of the brain structures that we analyzed most intensely over a period from the early 60s to the middle 90s.  We studied its normal development with 3H-thymidine autoradiography.  We used light microscopy and electron microscopy to study its development during prenatal and postnatal suckling period (birth to P21).  The same techniques were used to study the disorganized cerebellum after various exposures to postnatal X-irradiation.  We studied behavior in the cerebellar X-irradiated animals.  All of these studies culminated in our ability to explain how the normal cytoarchitecture of the cerebellar cortex arises during its postnatal development.

Cerebellar Development

For full-sized illustraions,
see: cerebellar illustrations.pdf


Links to Papers:

Altman 1982 review.pdf

Light and Electron Microscopy
Normal development

Altman et al Exp Neurol 17 1967.pdf
Altman et al Exp Neurol 21 1968.pdf
Altman et al Exp Neurol 24 1969.pdf
Altman&Anderson Exp Neurol 30 1971.pdf
Altman&Anderson JCN 146 1972.pdf
Altman&Anderson JCN 149 1.pdf
Altman JCN 149 2.pdf
Altman JCN 149 3.pdf
Altman JCN 165 1 1976.pdf
Altman JCN 165 2 1976.pdf 
Altman JCN 165 3 1976.pdf

Functional Studies, Including Behavior,
Transplantation and Biochemical Manipulations

Wallace&Altman 1970 1.pdf
Wallace&Altman 1970 2.pdf
Das&Altman Br Res 38 1972.pdf
Nichelson&Altman Science 176 1972.pdf
Nicholson&Altman Br Res 44 1972 1.pdf
Nicholson&Altman Br Res 44 1972 2.pdf
BauerMoffett&Altman Exp Neurol 1975.pdf
Pellegrino&Altman JCPP 1979.pdf
Gruner et al ExBrRes 1980.pdf
Gruner&Altman ExBrRes 1980.pdf

Embryonic Development of the
Cerebellum and Precerebellar System

Altman&Bayer JCN 179 1.pdf
Altman&Bayer JCN 179 2.pdf
Altman&Bayer JCN 231 1.pdf
Altman&Bayer JCN 231 2.pdf
Altman&Bayer JCN 231 3.pdf
Altman&Bayer JCN 257 1.pdf
Altman&Bayer JCN 257 2.pdf
Altman&Bayer JCN 257 3.pdf
Altman&Bayer JCN 257 4.pdf


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